Mental Health and Brain Health: Depression, Mood, and Dementia Risk
Depression is one of the 14 modifiable risk factors — but the link is more nuanced, and more hopeful, than the headlines suggest.
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Specific, actionable guides on the topics that matter most.
Depression is one of the 14 modifiable risk factors — but the link is more nuanced, and more hopeful, than the headlines suggest.
Read the guide →Sleep changes as you age — here are the habits with the strongest research behind them, and why they matter more after 50.
Read the guide →What matters most for your brain in your 40s, 50s, 60s, and beyond — the same 14 risk factors don't carry equal weight at every age.
Read the guide →What the trial behind this site's five-domain framework actually found — and what it didn't prove.
Read the guide →Why untreated hearing and vision loss are now among the biggest modifiable dementia risk factors — and what treating them shows.
Read the guide →Why blood pressure, cholesterol, and blood sugar are among the most modifiable influences on your dementia risk.
Read the guide →Resistance training activates different brain pathways than aerobic exercise. Here's what the emerging evidence shows — and how much you need.
Read the guide →Not all mental activity builds cognitive reserve. Research points to activities with specific properties — here's what the evidence actually supports, ranked.
Read the guide →A 2024 analysis of 600,000+ people found loneliness carries a 31% increased dementia risk — comparable to physical inactivity. Here's what's happening in the brain, and what to do about it.
Read the guide →Every night of poor sleep disrupts memory consolidation and brain waste clearance. Here's what the research shows — and the one habit change with the strongest evidence.
Read the guide →Some people show no dementia symptoms despite significant brain changes. The difference often comes down to cognitive reserve — and it's something you can actively build.
Read the guide →The glymphatic system, beta-amyloid clearance, and why deep sleep may be one of your brain's most important maintenance windows.
Read the guide →One of the largest modifiable dementia risk factors gets almost no attention — and it's one you can address today.
Read the guide →Six types of exercise ranked by evidence — what the research says, how much you need, and how to start.
Read the guide →The research gives a surprisingly specific answer. Here's how much, how often, how fast — and what happens in your brain when you do it.
Read the guide →They overlap heavily but differ in specifics. Here's what the research says about each — and which one to actually follow.
Read the guide →What to buy, what to limit, and why — the MIND diet translated into a practical shopping list with the evidence behind every category.
Read the guide →The research-backed cognitive activities that actually build reserve and protect memory — ranked by the strength of evidence behind them.
Read the guide →How specific types of movement clear mental fog, sharpen focus, and restore mental energy — with protocols you can start this week.
Read the guide →A practical 7-day meal plan built around the MIND diet, with a grocery list, breakfast ideas, and simple recipes for beginners.
Read the guide →The research-backed foods that consistently show up in brain health studies — and the ones worth limiting.
Read the guide →Every recommendation on this site traces back to peer-reviewed research. Here are some of the landmark studies that inform our guidance.